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With the advent of nicotine replacement therapy, the consumption of the nicotine is on the rise.

Nicotine is considered to be a safer alternative of tobacco. The IARC monograph has not included nicotine as a carcinogen. However there are various studies which show.

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We undertook this review to specifically evaluate the effects of nicotine on the various organ systems. A computer aided search of the Medline and PubMed database was done using a combination of the keywords. All the animal and human studies investigating only the role of nicotine were included.

Nicotine poses several health hazards. There is an increased risk of cardiovascular, respiratory, gastrointestinal disorders. There is decreased immune response and it also poses ill impacts on the reproductive health.

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Pall Mall Pall Mall Red s. Author Info Updated: September 12, Vasc Med. Nicotine stimulates vagal reflex and parasympathetic ganglia and causes an increased airway resistance by causing bronchoconstriction.

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Nicotine and cotinine has been found to be present in the breast fluid of lactating women. Not Helpful 7 Helpful 5.

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